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LAR-RPTPs Directly Interact with Neurexins to Coordinate Bidirectional Assembly of Molecular Machineries

Kyung Ah Han, Yoon-Jung Kim, Taek Han Yoon, Hyeonho Kim, Sungwon Bae, Ji Won Um, Se-Young Choi, and Jaewon Ko

Synaptic adhesions are critical components for synaptogenesis. Han et al. identify physical interactions of neurexins with leukocyte common-antigen related receptor tyrosine phosphatases (LAR-RPTPs) that are regulated by availability of heparan sulfates and alternative splicing of LAR-RPTPs. Neurexins and LAR-RPTPs cooperate in presynaptic assembly, whereas they competitively function in postsynaptic differentiation. Drosophila orthologs of neurexins and LAR-RPTPs control structure and function at neuromuscular junctions. This study sheds light on how trans-synaptic signals bidirectionally orchestrate synapse organization.