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"Experimental & Molecular Medicine" 종설논문 게재 (06.01.2023)

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댓글 0건 조회 450회 작성일 2023-06-14 07:00

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WAVE regulatory complex 구성요소들에 의한 신경세포 액틴 구조, 기능, 그리고 시냅스/신경회로 특성을 조절하는데 관여하는 다양한 최근 연구결과들을 정리한 종설논문이 Experimental and Molecular Medicine지에 발표되었습니다. 연구실에서는 한경아 연구교수가 제1저자로 작업에 참여하였습니다. 축하드립니다.


Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization


1Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), 333 Techno Jungangdae-Ro, Hyeonpoong-Eup, Dalseong-Gun, Daegu, 42988, Korea.
2Center for Synapse Diversity and Specificity, DGIST, Daegu, 42988, Korea.
3Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), 333 Techno Jungangdae-Ro, Hyeonpoong-Eup, Dalseong-Gun, Daegu, 42988, Korea. jaewonko@dgist.ac.kr.
4Center for Synapse Diversity and Specificity, DGIST, Daegu, 42988, Korea. jaewonko@dgist.ac.kr.

Abstract

The WAVE regulatory complex (WRC), composed of five components-Cyfip1/Sra1, WAVE/Scar, Abi, Nap1/Nckap1, and Brk1/HSPC300-is essential for proper actin cytoskeletal dynamics and remodeling in eukaryotic cells, likely by matching various patterned signals to Arp2/3-mediated actin nucleation. Accumulating evidence from recent studies has revealed diverse functions of the WRC in neurons, demonstrating its crucial role in dictating the assembly of molecular complexes for the patterning of various trans-synaptic signals. In this review, we discuss recent exciting findings on the physiological role of the WRC in regulating synaptic properties and highlight the involvement of WRC dysfunction in various brain disorders.

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